Changes in metabolite, energy metabolism related enzyme activities and peripheral blood mononuclear cell (PBMC) populations in beef heifers with two differing liveweight change profiles in New Zealand

TitleChanges in metabolite, energy metabolism related enzyme activities and peripheral blood mononuclear cell (PBMC) populations in beef heifers with two differing liveweight change profiles in New Zealand
Publication TypeJournal Article
Year of Publication2008
AuthorsMori, A., Kenyon P R., Mori N., Yamamoto I., Tanaka Y., Suzuki N., Tazaki H., Ozawa T., Hayashi T., Hickson R E., Morris S T., Blair H., and Arai T.
JournalVeterinary Research Communications
Volume32
Issue2
Pagination159 - 166
Date Published2008
ISBN Number01657380 (ISSN)
Keywordsalanine aminotransferase, analytical parameters, Animal Feed, animal food, animal husbandry, Animals, article, aspartate aminotransferase, Beef cattle, beef heifer, body weight, cattle, CD3 antigen, CD3 cell, cell enzyme, cholesterol, controlled study, cytosol, diet restriction, energy metabolism, enzyme activity, fatty acid, fatty acid blood level, female, glucose, heifer, immunity, immunoreactive insulin, insulin blood level, lactate dehydrogenase, lactic acid, leukocyte count, Leukocytes, Mononuclear, Liveweight, malate dehydrogenase, MDH, Metabolite, mitochondrial enzyme, natural killer cell, New Zealand, nonhuman, peripheral blood mononuclear cell, Pregnancy, pyruvic acid, triacylglycerol, weight change, weight gain, weight reduction
Abstract

Metabolite and immunoreactive insulin (IRI) concentrations, energy metabolism related enzymes activities and peripheral blood mononuclear cell (PBMC) populations were measured in blood of pregnant Angus heifers with differing liveweight change profiles (gaining or losing), in New Zealand to investigate the meanings of those parameters in the restricted feeding beef heifers. Beef heifers losing liveweight (412 g/day) showed significantly lower concentrations of plasma IRI, and higher concentrations of plasma free fatty acid (FFA) than heifers gaining liveweight (483 g/day). The cytosolic and mitochondrial malate dehydrogenase (MDH) activities and MDH/lactate dehydrogenase (M/L) ratio in leukocytes of the liveweight losing heifers were significantly higher than those the liveweight gaining heifers. Percentages of cluster of differentiation (CD) 3 positive cells and natural killer (NK) cells in PBMC decreased significantly in the liveweight losing heifers compared to those in the liveweight gaining heifers. Plasma IRI and FFA concentrations, leukocyte cytosolic and mitochondrial MDH activities and CD3 positive and NK cell populations may be useful markers to evaluate metabolic conditions and immunity in the restricted feeding beef heifers. © Springer Science + Business Media B.V. 2007.

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