An evaluation of the copper sequestrated during clotting in cattle: Is it just caeruloplasmin?

TitleAn evaluation of the copper sequestrated during clotting in cattle: Is it just caeruloplasmin?
Publication TypeJournal Article
Year of Publication2008
AuthorsLaven, R, Lawrence K.E., and Livesey C.T.
JournalVeterinary Journal
Volume176
Issue3
Pagination397 - 399
Date Published2008
ISBN Number10900233 (ISSN)
KeywordsAnimals, article, atomic absorption spectrometry, blood clotting, Blood Coagulation, blood sampling, Bos, cattle, ceruloplasmin, ceruloplasmin blood level, confidence interval, controlled study, copper, copper blood level, CP, herd, nonhuman, plasma, regression analysis, Serum
Abstract

In cattle, sequestration of copper (Cu) occurs during the clotting process so that serum Cu concentrations are markedly lower than plasma Cu. It has been suggested that all of the Cu lost during clotting is caeruloplasmin (CP). This study used paired samples from 125 cattle to assess whether this assumption was correct. The regression equations for plasma CP activity against plasma Cu concentration and serum CP against serum Cu had significantly different intercepts suggesting that at zero CP activity the amount of Cu remaining was dependent on sample type. Furthermore, the difference between serum and plasma Cu was unrelated to Cu status, whereas the difference between serum and plasma CP was related to Cu status. The regression equation for the loss of CP activity against change in Cu concentration had an intercept that was different from zero, indicating that a reduction in Cu concentration could occur even if CP activity was unaffected by clotting. © 2007 Elsevier Ltd. All rights reserved.

URLhttp://www.scopus.com/inward/record.url?eid=2-s2.0-43049120348&partnerID=40&md5=421369aadad0ea75cc533646e56341e8
Go to top